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What is Tesamorelin?
Tesamorelin is a stabilized analog of growth-hormone-releasing hormone studied for its reported effect on visceral adipose tissue - the fat surrounding internal organs - in metabolic research models.
How Tesamorelin works (research mechanism)
Tesamorelin stimulates endogenous GH release like other GHRH analogs, with research focused specifically on visceral-fat endpoints rather than subcutaneous fat.
Primary research applications
Visceral-fat research
Studied specifically for visceral adipose tissue endpoints.
Metabolic-health models
Examined for broader metabolic-syndrome research variables.
GHRH-axis research
Used as a GHRH analog in GH-release studies.
Research dosing reference
Research references commonly cite 1-2 mg daily. Reference values only.
Reconstitution & handling
Tesamorelin ships as a lyophilized (freeze-dried) powder and must be reconstituted before use in any liquid research model. Allow the vial to reach room temperature, swab the stopper, then add bacteriostatic water slowly down the inside wall of the vial - never spray it directly onto the powder. Swirl gently until dissolved; do not shake, as shaking foams the solution and stresses the peptide. The volume of water you add sets the concentration: a 5 mg vial reconstituted with 2 mL yields 2,500 mcg/mL, so 0.1 mL measures 250 mcg. A correctly reconstituted Tesamorelin solution is clear; discard if it is cloudy or shows particulate.
Storage & stability
Store un-reconstituted Tesamorelin vials refrigerated and protected from light for long-term stability; the lyophilized form is robust and tolerates shipping. After reconstitution, refrigerate at 2-8C, keep away from light, and use within the typical research window of roughly two to four weeks. The benzyl alcohol in bacteriostatic water helps inhibit microbial growth across that period. Always label reconstituted vials with the concentration and date.
Common research pairings
Studied as a standalone GHRH analog in metabolic research.
How Tesamorelin compares
Tesamorelin is studied for visceral fat specifically, distinguishing it from AOD 9604 (general lipolysis) and the GLP-1 peptides (appetite).
Safety & research considerations
Tesamorelin is supplied for research use only and is not for human consumption.
Tesamorelin research reference data
The figures below are reference values compiled from the research literature for laboratory study design only. They are not instructions for any living subject. See the full Tesamorelin research reference for complete detail and citations.
Half-life and exposure. Approx. 8-11 min depending formulation
Pharmacokinetics (research reference). FDA labeling for tesamorelin formulations reports very short elimination half-life values, roughly 8-11 minutes depending formulation; downstream GH/IGF-1 signaling persists beyond plasma presence.
Tesamorelin dose-reference table
| Reference dose | Units (U-100 syringe) |
|---|---|
| 0.5 mg | 10 units |
| 1 mg | 20 units |
| 2 mg | 40 units |
Reconstitution and concentration by vial size
| Vial | Reconstitute with | Concentration |
|---|---|---|
| 10 mg | 2 mL BAC Water | 0.050 mg/unit |
| 20 mg | 2 mL BAC Water | 0.100 mg/unit |
Research timing. Often used before bed or during fasted windows to align with GH-axis signaling and reduce food-related interference.
Dose-escalation reference. Begin conservatively while monitoring hunger, edema, sleep quality, glucose response, and tingling/carpal-tunnel-like symptoms.
Monitoring in research models. Monitor water retention, increased hunger, flushing, glucose variability, joint stiffness, or tingling. Periodic IGF-1 and glucose monitoring may be appropriate in longer protocols.
Reassessment cadence. GH-axis protocols should reassess every 8-12 weeks: IGF-1, fasting glucose/A1c where appropriate, edema, sleep quality, hunger, body-composition objectives, and continued need.
Stacking notes (research). GH-axis agents stack most logically with complementary GH secretagogues; avoid overbuilding GH-axis stacks without monitoring IGF-1, glucose, and edema response.
Sourcing, purity & Certificate of Analysis
Every lot of Tesamorelin sold by Peptides Factory Direct is third-party tested to a 99%+ purity target, with identity confirmed by mass spectrometry and purity quantified by HPLC. A Certificate of Analysis (COA) documenting these results is available on request and ties each vial to a tracked lot. Material ships nationwide to all 50 US states with cold-chain handling where appropriate and fast domestic dispatch. This documentation is what separates research-grade Tesamorelin from unverified material - quality is established before the vial ever reaches your lab.
How to order Tesamorelin for research
Tesamorelin can be ordered through the Peptides Factory Direct research portal as a one-time purchase or on a recurring research schedule (every 2 weeks, monthly, every 2 months, or every 3 months). Checkout requires confirming you are 21 or older, purchasing for laboratory research only, and that the product is not for human or animal consumption. Bulk and standing-order pricing is available - note it in your order. Open the order portal to view current research sizes and pricing.
Frequently asked questions
What is tesamorelin researched for?
Visceral-fat and metabolic-health endpoints via GHRH-mediated GH release. Research use only.
What sizes are available?
5 mg and 10 mg vials, third-party tested, COA on request.
Is tesamorelin for human use?
No - supplied strictly for laboratory research.
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External references: Peptides (Wikipedia) · U.S. Food and Drug Administration