What is TB-500?
TB-500 is a synthetic peptide corresponding to the active region of Thymosin Beta-4, a naturally occurring protein involved in actin regulation and cell migration. In research it is valued for its reported ability to travel systemically and reach tissue throughout the body rather than acting only at a local site.
How TB-500 works (research mechanism)
TB-500 research focuses on its binding to G-actin and its role in cell migration, blood-vessel formation, and the recruitment of repair cells to damaged tissue. By promoting cell motility, it is studied as a driver of slower but deeper regeneration than localized repair peptides.
Primary research applications
Deep tissue and muscle recovery research
TB-500 is studied across muscle, tendon, and ligament models where whole-body distribution is desirable, and in flexibility and range-of-motion research.
Chronic-injury models
Its systemic profile makes it common in chronic and hard-to-reach injury models where a localized peptide would be impractical.
Stacked regeneration studies
It is the standard research partner for BPC-157 in connective-tissue regeneration protocols.
Research dosing reference
Published research references commonly cite a loading phase of 5-10 mg per week split across 2-3 administrations for 4-6 weeks, followed by a 2-5 mg per week maintenance figure. These are reference values from the literature and are not instructions for any living subject.
Reconstitution & handling
TB-500 ships as a lyophilized (freeze-dried) powder and must be reconstituted before use in any liquid research model. Allow the vial to reach room temperature, swab the stopper, then add bacteriostatic water slowly down the inside wall of the vial - never spray it directly onto the powder. Swirl gently until dissolved; do not shake, as shaking foams the solution and stresses the peptide. The volume of water you add sets the concentration: a 5 mg vial reconstituted with 2 mL yields 2,500 mcg/mL, so 0.1 mL measures 250 mcg. A correctly reconstituted TB-500 solution is clear; discard if it is cloudy or shows particulate.
Storage & stability
Store un-reconstituted TB-500 vials refrigerated and protected from light for long-term stability; the lyophilized form is robust and tolerates shipping. After reconstitution, refrigerate at 2-8C, keep away from light, and use within the typical research window of roughly two to four weeks. The benzyl alcohol in bacteriostatic water helps inhibit microbial growth across that period. Always label reconstituted vials with the concentration and date.
Common research pairings
TB-500 + BPC-157 is the most-studied healing pair in the literature; the two are reported to address complementary repair pathways. TB-500 is banned by WADA, a relevant note for sports-science researchers.
How TB-500 compares
Where BPC-157 is studied as fast and local, TB-500 is studied as slower and systemic. Researchers often choose between them based on whether whole-body distribution or site-specific action is the variable of interest.
Safety & research considerations
TB-500 is a research chemical with no approved human indication and no recognized clinical safety profile. It is for in-vitro and laboratory research only.
Sourcing, purity & Certificate of Analysis
Every lot of TB-500 sold by Peptides Factory Direct is third-party tested to a 99%+ purity target, with identity confirmed by mass spectrometry and purity quantified by HPLC. A Certificate of Analysis (COA) documenting these results is available on request and ties each vial to a tracked lot. Material ships nationwide to all 50 US states with cold-chain handling where appropriate and fast domestic dispatch. This documentation is what separates research-grade TB-500 from unverified material - quality is established before the vial ever reaches your lab.
How to order TB-500 for research
TB-500 can be ordered through the Peptides Factory Direct research portal as a one-time purchase or on a recurring research schedule (every 2 weeks, monthly, every 2 months, or every 3 months). Checkout requires confirming you are 21 or older, purchasing for laboratory research only, and that the product is not for human or animal consumption. Bulk and standing-order pricing is available - note it in your order. Open the order portal to view current research sizes and pricing.
Frequently asked questions
What is TB-500 researched for?
Deep-tissue and muscle recovery, flexibility, and chronic-injury models, often alongside BPC-157. Research use only - not for human consumption.
What sizes are available?
5 mg and 10 mg lyophilized vials, third-party tested, COA on request.
Why is TB-500 studied systemically?
Its reported ability to distribute throughout the body makes it useful in models where localized peptides cannot reach the target tissue.
Is TB-500 FDA approved?
No. It is a research chemical, not FDA approved, and not for human or animal use.
How should TB-500 be stored?
Refrigerate the lyophilized vial away from light; refrigerate after reconstitution and use within the typical research window.
Is a COA available?
Yes, a Certificate of Analysis is available on request for the lots we ship.
Related Healing & Recovery peptides
All Healing & Recovery peptides · Research guides & articles
External references: Peptides (Wikipedia) · U.S. Food and Drug Administration