What is KPV?
KPV is the C-terminal tripeptide (lysine-proline-valine) of the alpha-melanocyte-stimulating hormone. In research it is studied because it retains anti-inflammatory activity associated with the parent hormone without the pigmentation effects, making it a clean model compound for inflammation studies.
How KPV works (research mechanism)
KPV research focuses on its reported ability to enter cells and modulate inflammatory transcription pathways (such as NF-kB signaling), reducing pro-inflammatory cytokine output in models of gut and tissue inflammation.
Primary research applications
Gut inflammation models
KPV is studied in models relevant to inflammatory bowel research (such as colitis and Crohn-type models) where epithelial inflammation is the variable.
General anti-inflammatory research
It is used as a model peptide for systemic and tissue inflammation studies with minimal off-target signaling.
Immune-modulation research
Its melanocortin lineage makes it relevant to immune-signaling investigations.
Research dosing reference
Research references commonly cite 500-1,000 mcg daily across a 4-12 week study window. Reference values only - not dosing for any subject.
Reconstitution & handling
KPV ships as a lyophilized (freeze-dried) powder and must be reconstituted before use in any liquid research model. Allow the vial to reach room temperature, swab the stopper, then add bacteriostatic water slowly down the inside wall of the vial - never spray it directly onto the powder. Swirl gently until dissolved; do not shake, as shaking foams the solution and stresses the peptide. The volume of water you add sets the concentration: a 5 mg vial reconstituted with 2 mL yields 2,500 mcg/mL, so 0.1 mL measures 250 mcg. A correctly reconstituted KPV solution is clear; discard if it is cloudy or shows particulate.
Storage & stability
Store un-reconstituted KPV vials refrigerated and protected from light for long-term stability; the lyophilized form is robust and tolerates shipping. After reconstitution, refrigerate at 2-8C, keep away from light, and use within the typical research window of roughly two to four weeks. The benzyl alcohol in bacteriostatic water helps inhibit microbial growth across that period. Always label reconstituted vials with the concentration and date.
Common research pairings
In healing research KPV is sometimes studied alongside BPC-157 for combined repair-and-inflammation models.
How KPV compares
Unlike BPC-157 and TB-500, which are studied for structural tissue repair, KPV is studied specifically for inflammatory signaling, making it complementary rather than competitive.
Safety & research considerations
KPV is a research chemical with no approved human use. For in-vitro and laboratory research only.
Sourcing, purity & Certificate of Analysis
Every lot of KPV sold by Peptides Factory Direct is third-party tested to a 99%+ purity target, with identity confirmed by mass spectrometry and purity quantified by HPLC. A Certificate of Analysis (COA) documenting these results is available on request and ties each vial to a tracked lot. Material ships nationwide to all 50 US states with cold-chain handling where appropriate and fast domestic dispatch. This documentation is what separates research-grade KPV from unverified material - quality is established before the vial ever reaches your lab.
How to order KPV for research
KPV can be ordered through the Peptides Factory Direct research portal as a one-time purchase or on a recurring research schedule (every 2 weeks, monthly, every 2 months, or every 3 months). Checkout requires confirming you are 21 or older, purchasing for laboratory research only, and that the product is not for human or animal consumption. Bulk and standing-order pricing is available - note it in your order. Open the order portal to view current research sizes and pricing.
Frequently asked questions
What is KPV used for in research?
Anti-inflammatory and gut-inflammation models, and immune-signaling research. Research use only.
What sizes are stocked?
5 mg and 10 mg vials, third-party tested, COA on request.
Is KPV FDA approved?
No - it is a research chemical, not for human or animal consumption.
How is KPV stored?
Refrigerate the lyophilized vial, protect from light, and refrigerate after reconstitution.
Related Healing & Recovery peptides
All Healing & Recovery peptides · Research guides & articles
External references: Peptides (Wikipedia) · U.S. Food and Drug Administration