PT-141 for Research

What is PT-141?

PT-141 (Bremelanotide) is a synthetic melanocortin-receptor agonist derived from Melanotan II. It is studied for sexual-function endpoints through a central-nervous-system mechanism rather than a vascular one.

How PT-141 works (research mechanism)

PT-141 research focuses on activation of melanocortin receptors (notably MC4R) in the central nervous system, which is the distinguishing feature versus vascular mechanisms studied for other compounds.

Primary research applications

Libido / sexual-function research

Studied for arousal endpoints in both male and female models via CNS signaling.

Melanocortin-pathway research

A model compound for MC4R signaling studies.

Centrally-mediated research

Used where a central rather than vascular mechanism is the variable.

Research dosing reference

Research references commonly cite 1-2 mg administered 45-90 minutes before the modeled endpoint, used as-needed rather than daily. Reference values only.

Reconstitution & handling

PT-141 ships as a lyophilized (freeze-dried) powder and must be reconstituted before use in any liquid research model. Allow the vial to reach room temperature, swab the stopper, then add bacteriostatic water slowly down the inside wall of the vial - never spray it directly onto the powder. Swirl gently until dissolved; do not shake, as shaking foams the solution and stresses the peptide. The volume of water you add sets the concentration: a 5 mg vial reconstituted with 2 mL yields 2,500 mcg/mL, so 0.1 mL measures 250 mcg. A correctly reconstituted PT-141 solution is clear; discard if it is cloudy or shows particulate.

Storage & stability

Store un-reconstituted PT-141 vials refrigerated and protected from light for long-term stability; the lyophilized form is robust and tolerates shipping. After reconstitution, refrigerate at 2-8C, keep away from light, and use within the typical research window of roughly two to four weeks. The benzyl alcohol in bacteriostatic water helps inhibit microbial growth across that period. Always label reconstituted vials with the concentration and date.

Common research pairings

Generally studied as a standalone melanocortin agonist.

How PT-141 compares

Unlike vascular-pathway compounds, PT-141 acts centrally; unlike Melanotan I/II it is studied primarily for sexual-function rather than tanning endpoints.

Safety & research considerations

PT-141 is supplied for research use only; the literature notes nausea and flushing in models. Not for human consumption.

Sourcing, purity & Certificate of Analysis

Every lot of PT-141 sold by Peptides Factory Direct is third-party tested to a 99%+ purity target, with identity confirmed by mass spectrometry and purity quantified by HPLC. A Certificate of Analysis (COA) documenting these results is available on request and ties each vial to a tracked lot. Material ships nationwide to all 50 US states with cold-chain handling where appropriate and fast domestic dispatch. This documentation is what separates research-grade PT-141 from unverified material - quality is established before the vial ever reaches your lab.

How to order PT-141 for research

PT-141 can be ordered through the Peptides Factory Direct research portal as a one-time purchase or on a recurring research schedule (every 2 weeks, monthly, every 2 months, or every 3 months). Checkout requires confirming you are 21 or older, purchasing for laboratory research only, and that the product is not for human or animal consumption. Bulk and standing-order pricing is available - note it in your order. Open the order portal to view current research sizes and pricing.

Frequently asked questions

Related Sexual Health & Tanning peptides

All Sexual Health & Tanning peptides · Research guides & articles

External references: Peptides (Wikipedia) · U.S. Food and Drug Administration