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What is Kisspeptin?
Kisspeptin is a neuropeptide encoded by the KISS1 gene that is a key upstream regulator of the reproductive hormone axis. It is studied for its reported ability to stimulate gonadotropin-releasing hormone (GnRH) and downstream hormone signaling.
How Kisspeptin works (research mechanism)
Kisspeptin research focuses on activation of GnRH neurons, which drives luteinizing-hormone signaling and the broader reproductive axis - a model for fertility and hormone research.
Primary research applications
Fertility / reproductive research
Studied for GnRH and gonadotropin endpoints.
Hormone-axis research
Examined as an upstream regulator of reproductive hormones.
Libido-signaling research
Studied for centrally-mediated reproductive endpoints.
Research dosing reference
Research references commonly cite 1-2 mg two to three times weekly. Reference values only.
Reconstitution & handling
Kisspeptin ships as a lyophilized (freeze-dried) powder and must be reconstituted before use in any liquid research model. Allow the vial to reach room temperature, swab the stopper, then add bacteriostatic water slowly down the inside wall of the vial - never spray it directly onto the powder. Swirl gently until dissolved; do not shake, as shaking foams the solution and stresses the peptide. The volume of water you add sets the concentration: a 5 mg vial reconstituted with 2 mL yields 2,500 mcg/mL, so 0.1 mL measures 250 mcg. A correctly reconstituted Kisspeptin solution is clear; discard if it is cloudy or shows particulate.
Storage & stability
Store un-reconstituted Kisspeptin vials refrigerated and protected from light for long-term stability; the lyophilized form is robust and tolerates shipping. After reconstitution, refrigerate at 2-8C, keep away from light, and use within the typical research window of roughly two to four weeks. The benzyl alcohol in bacteriostatic water helps inhibit microbial growth across that period. Always label reconstituted vials with the concentration and date.
Common research pairings
Generally studied as a standalone hormone-axis regulator.
How Kisspeptin compares
Kisspeptin acts upstream of GnRH itself, distinguishing it from Gonadorelin (a GnRH peptide) and HCG (an LH analog).
Safety & research considerations
A research-stage peptide not approved for human use. For laboratory research only.
Kisspeptin research reference data
The figures below are reference values compiled from the research literature for laboratory study design only. They are not instructions for any living subject. See the full Kisspeptin research reference for complete detail and citations.
Half-life and exposure. Short acting
Pharmacokinetics (research reference). Human pharmacokinetics are not standardized. Treat exposure as short acting unless compound-specific data or formal formulation labeling indicates otherwise.
Kisspeptin dose-reference table
| Reference dose | Units (U-100 syringe) |
|---|---|
| 100 mcg | 2 units |
| 250 mcg | 5 units |
| 500 mcg | 10 units |
Reconstitution and concentration by vial size
| Vial | Reconstitute with | Concentration |
|---|---|---|
| 10 mg | 2 mL BAC Water | 0.050 mg/unit |
Research timing. Often timed based on reproductive-axis objective; consistency and pulse logic matter.
Dose-escalation reference. Begin low and assess endocrine response before increasing frequency or dose.
Monitoring in research models. Monitor mood, libido changes, flushing, headache, or endocrine-axis symptoms.
Reassessment cadence. Use objective-driven, marker-aware courses. Reassess endocrine, mood, libido, blood-pressure, or target-symptom response before repeating or escalating.
Stacking notes (research). Avoid stacking with multiple HPG-axis agents without lab interpretation.
Sourcing, purity & Certificate of Analysis
Every lot of Kisspeptin sold by Peptides Factory Direct is third-party tested to a 99%+ purity target, with identity confirmed by mass spectrometry and purity quantified by HPLC. A Certificate of Analysis (COA) documenting these results is available on request and ties each vial to a tracked lot. Material ships nationwide to all 50 US states with cold-chain handling where appropriate and fast domestic dispatch. This documentation is what separates research-grade Kisspeptin from unverified material - quality is established before the vial ever reaches your lab.
How to order Kisspeptin for research
Kisspeptin can be ordered through the Peptides Factory Direct research portal as a one-time purchase or on a recurring research schedule (every 2 weeks, monthly, every 2 months, or every 3 months). Checkout requires confirming you are 21 or older, purchasing for laboratory research only, and that the product is not for human or animal consumption. Bulk and standing-order pricing is available - note it in your order. Open the order portal to view current research sizes and pricing.
Frequently asked questions
What is Kisspeptin researched for?
Fertility, reproductive-hormone-axis, and libido-signaling endpoints via GnRH stimulation. Research use only.
What sizes are stocked?
5 mg and 10 mg vials, third-party tested, COA on request.
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External references: Peptides (Wikipedia) · U.S. Food and Drug Administration