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What is Ipamorelin?
Ipamorelin is a pentapeptide and a selective growth-hormone secretagogue (a GHRP). In research it is valued for being one of the most selective GHRPs, reported to stimulate GH release with minimal effect on cortisol or prolactin compared with older GHRPs.
How Ipamorelin works (research mechanism)
Ipamorelin acts on the ghrelin/GH-secretagogue receptor to trigger growth-hormone release. Its selectivity is the central research interest, since it isolates the GH-release variable without confounding hormonal signals.
Primary research applications
Selective GH-release research
Used as a clean GHRP in studies where minimizing cortisol/prolactin interference matters.
GHRH synergy models
Most often studied with CJC-1295 to amplify GH pulses.
Body-composition and recovery research
Downstream metabolic and recovery endpoints are studied in models.
Research dosing reference
Research references commonly cite 200-300 mcg before rest periods on a 5-7 day schedule. Reference values only.
Reconstitution & handling
Ipamorelin ships as a lyophilized (freeze-dried) powder and must be reconstituted before use in any liquid research model. Allow the vial to reach room temperature, swab the stopper, then add bacteriostatic water slowly down the inside wall of the vial - never spray it directly onto the powder. Swirl gently until dissolved; do not shake, as shaking foams the solution and stresses the peptide. The volume of water you add sets the concentration: a 5 mg vial reconstituted with 2 mL yields 2,500 mcg/mL, so 0.1 mL measures 250 mcg. A correctly reconstituted Ipamorelin solution is clear; discard if it is cloudy or shows particulate.
Storage & stability
Store un-reconstituted Ipamorelin vials refrigerated and protected from light for long-term stability; the lyophilized form is robust and tolerates shipping. After reconstitution, refrigerate at 2-8C, keep away from light, and use within the typical research window of roughly two to four weeks. The benzyl alcohol in bacteriostatic water helps inhibit microbial growth across that period. Always label reconstituted vials with the concentration and date.
Common research pairings
Ipamorelin + CJC-1295 (no DAC) is the standard research stack for amplified, relatively clean GH release.
How Ipamorelin compares
Compared with GHRP-6 and GHRP-2, Ipamorelin is studied as the most selective option with the least off-target hormonal signaling; compared with Hexarelin it is gentler but less potent.
Safety & research considerations
Ipamorelin is a research chemical with no approved human use. For laboratory research only.
Ipamorelin research reference data
The figures below are reference values compiled from the research literature for laboratory study design only. They are not instructions for any living subject. See the full Ipamorelin research reference for complete detail and citations.
Half-life and exposure. Short acting
Pharmacokinetics (research reference). Human pharmacokinetics are not standardized. Treat exposure as short acting unless compound-specific data or formal formulation labeling indicates otherwise.
Ipamorelin dose-reference table
| Reference dose | Units (U-100 syringe) |
|---|---|
| 100 mcg | 2 units |
| 200 mcg | 4 units |
| 300 mcg | 6 units |
Reconstitution and concentration by vial size
| Vial | Reconstitute with | Concentration |
|---|---|---|
| 10 mg | 2 mL BAC Water | 0.050 mg/unit |
Research timing. Often used before bed or during fasted windows to align with GH-axis signaling and reduce food-related interference.
Dose-escalation reference. Begin conservatively while monitoring hunger, edema, sleep quality, glucose response, and tingling/carpal-tunnel-like symptoms.
Monitoring in research models. Monitor water retention, increased hunger, flushing, glucose variability, joint stiffness, or tingling. Periodic IGF-1 and glucose monitoring may be appropriate in longer protocols.
Reassessment cadence. GH-axis protocols should reassess every 8-12 weeks: IGF-1, fasting glucose/A1c where appropriate, edema, sleep quality, hunger, body-composition objectives, and continued need.
Stacking notes (research). GH-axis agents stack most logically with complementary GH secretagogues; avoid overbuilding GH-axis stacks without monitoring IGF-1, glucose, and edema response.
Sourcing, purity & Certificate of Analysis
Every lot of Ipamorelin sold by Peptides Factory Direct is third-party tested to a 99%+ purity target, with identity confirmed by mass spectrometry and purity quantified by HPLC. A Certificate of Analysis (COA) documenting these results is available on request and ties each vial to a tracked lot. Material ships nationwide to all 50 US states with cold-chain handling where appropriate and fast domestic dispatch. This documentation is what separates research-grade Ipamorelin from unverified material - quality is established before the vial ever reaches your lab.
How to order Ipamorelin for research
Ipamorelin can be ordered through the Peptides Factory Direct research portal as a one-time purchase or on a recurring research schedule (every 2 weeks, monthly, every 2 months, or every 3 months). Checkout requires confirming you are 21 or older, purchasing for laboratory research only, and that the product is not for human or animal consumption. Bulk and standing-order pricing is available - note it in your order. Open the order portal to view current research sizes and pricing.
Frequently asked questions
Why is Ipamorelin called a "clean" GHRP?
In research it stimulates GH release with minimal cortisol or prolactin response compared with older GHRPs - useful when isolating the GH variable.
What is Ipamorelin paired with?
Most commonly CJC-1295 in research stacks.
What sizes are available?
5 mg and 10 mg vials, third-party tested, COA on request.
Is Ipamorelin FDA approved?
No, it is a research chemical, not for human consumption.
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External references: Peptides (Wikipedia) · U.S. Food and Drug Administration