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What is IGF-1 LR3?
IGF-1 LR3 is a modified, long-acting analog of insulin-like growth factor 1, with an 83-amino-acid structure and a reduced affinity for binding proteins that gives it an extended active half-life in research models.
How IGF-1 LR3 works (research mechanism)
IGF-1 LR3 research focuses on IGF-1-receptor activation driving cell proliferation, nutrient partitioning, and anabolic signaling. Its extended half-life is the defining research feature versus native IGF-1.
Primary research applications
Anabolic / growth research
Among the most-studied peptides for cellular growth and protein-synthesis models.
Nutrient-partitioning research
Studied for its reported influence on substrate handling.
Recovery models
Examined for tissue-recovery endpoints in cycled research designs.
Research dosing reference
Research references commonly cite 40-80 mcg daily in 4-6 week cycled study windows. Reference values only - an advanced research compound.
Reconstitution & handling
IGF-1 LR3 ships as a lyophilized (freeze-dried) powder and must be reconstituted before use in any liquid research model. Allow the vial to reach room temperature, swab the stopper, then add bacteriostatic water slowly down the inside wall of the vial - never spray it directly onto the powder. Swirl gently until dissolved; do not shake, as shaking foams the solution and stresses the peptide. The volume of water you add sets the concentration: a 5 mg vial reconstituted with 2 mL yields 2,500 mcg/mL, so 0.1 mL measures 250 mcg. A correctly reconstituted IGF-1 LR3 solution is clear; discard if it is cloudy or shows particulate.
Storage & stability
Store un-reconstituted IGF-1 LR3 vials refrigerated and protected from light for long-term stability; the lyophilized form is robust and tolerates shipping. After reconstitution, refrigerate at 2-8C, keep away from light, and use within the typical research window of roughly two to four weeks. The benzyl alcohol in bacteriostatic water helps inhibit microbial growth across that period. Always label reconstituted vials with the concentration and date.
Common research pairings
IGF-1 LR3 is studied in cycled designs rather than continuous use, sometimes following GH-secretagogue protocols.
How IGF-1 LR3 compares
Where GHRPs and GHRH analogs stimulate endogenous GH, IGF-1 LR3 supplies a downstream IGF signal directly, making it a distinct and more advanced research tool.
Safety & research considerations
IGF-1 LR3 is a research chemical not approved for human use; the literature notes hypoglycemia risk in models. For laboratory research only and not for beginners.
IGF-1 LR3 research reference data
The figures below are reference values compiled from the research literature for laboratory study design only. They are not instructions for any living subject. See the full IGF-1 LR3 research reference for complete detail and citations.
Half-life and exposure. Extended vs native IGF-1; context dependent
Pharmacokinetics (research reference). LR3 modification extends functional exposure compared with native IGF-1. Human research-use PK depends on formulation and route; glucose-aware interpretation is required.
IGF-1 LR3 dose-reference table
| Reference dose | Units (U-100 syringe) |
|---|---|
| 10 mcg | 1 units |
| 20 mcg | 2 units |
| 40 mcg | 4 units |
Reconstitution and concentration by vial size
| Vial | Reconstitute with | Concentration |
|---|---|---|
| 1 mg | 1 mL AA water preferred for stability; dilute only if protocol requires | 0.010 mg/unit |
Research timing. Often placed around training or recovery windows; avoid first exposures when glucose cannot be monitored.
Dose-escalation reference. Begin very conservatively due to glucose implications and receptor potency.
Monitoring in research models. Monitor hypoglycemia-like symptoms, fatigue, edema, numbness/tingling, and glucose response.
Reassessment cadence. Use short, glucose-aware blocks with frequent reassessment. Avoid prolonged or stacked IGF-axis exposure without marker review and clear objective.
Stacking notes (research). Avoid combining aggressively with insulin-sensitizing or GH/IGF-heavy stacks without monitoring.
Sourcing, purity & Certificate of Analysis
Every lot of IGF-1 LR3 sold by Peptides Factory Direct is third-party tested to a 99%+ purity target, with identity confirmed by mass spectrometry and purity quantified by HPLC. A Certificate of Analysis (COA) documenting these results is available on request and ties each vial to a tracked lot. Material ships nationwide to all 50 US states with cold-chain handling where appropriate and fast domestic dispatch. This documentation is what separates research-grade IGF-1 LR3 from unverified material - quality is established before the vial ever reaches your lab.
How to order IGF-1 LR3 for research
IGF-1 LR3 can be ordered through the Peptides Factory Direct research portal as a one-time purchase or on a recurring research schedule (every 2 weeks, monthly, every 2 months, or every 3 months). Checkout requires confirming you are 21 or older, purchasing for laboratory research only, and that the product is not for human or animal consumption. Bulk and standing-order pricing is available - note it in your order. Open the order portal to view current research sizes and pricing.
Frequently asked questions
Why is IGF-1 LR3 considered advanced?
Its potent, long-acting anabolic signaling and noted hypoglycemia risk in models make it a tool for experienced researchers. Research use only.
What size is stocked?
1 mg lyophilized vial, third-party tested, COA on request.
Is IGF-1 LR3 FDA approved?
No, it is a research chemical and not for human consumption.
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External references: Peptides (Wikipedia) · U.S. Food and Drug Administration