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Mechanism of action
VIP is a vasoactive intestinal peptide acting through VPAC receptors with roles in vasodilation, bronchodilation, immune modulation, gut signaling, and neuroendocrine regulation.
Half-life & pharmacokinetics
Half-life: Short acting.
Human pharmacokinetics are not standardized. Treat exposure as short acting unless compound-specific data or formal formulation labeling indicates otherwise.
Research dosing reference
100-500 mcg daily or protocol-specific exposure depending on route and tolerance.
Dose interpretation (U-100 units)
| Target dose | U-100 units |
|---|---|
| 100 mcg | 2 units |
| 250 mcg | 5 units |
| 500 mcg | 10 units |
Units are concentration-specific - confirm against your actual reconstitution volume.
Reconstitution & concentration
| Vial | Preferred reconstitution | Final concentration |
|---|---|---|
| 10 mg | 2 mL BAC Water | 0.050 mg/unit |
Injection timing
Often used earlier in day or protocol-specific windows; monitor hemodynamic response.
Beginner escalation
Begin low due to vasodilatory and immune-modulatory effects.
Side-effect mitigation
Monitor flushing, blood pressure changes, headache, dizziness, GI effects, or immune response shifts.
Stack compatibility
Use caution with blood-pressure-active or immune-modulatory agents.
Storage & stability
Lyophilized: refrigerated or controlled cool storage. Reconstituted: refrigerated, protected from heat/light, and handled aseptically.
Protocol duration & reassessment
Short protocol blocks with blood-pressure and symptom reassessment are preferred before extension or repeat course.
Frequently asked questions
What is VIP and how does it work?
VIP is a vasoactive intestinal peptide acting through VPAC receptors with roles in vasodilation, bronchodilation, immune modulation, gut signaling, and neuroendocrine regulation.
What is the half-life of VIP?
VIP: Short acting. Human pharmacokinetics are not standardized. Treat exposure as short acting unless compound-specific data or formal formulation labeling indicates otherwise.
How is VIP reconstituted for research?
Preferred reconstitution for the 10 mg vial is 2 mL BAC Water, giving 0.050 mg/unit. Always confirm concentration math before any use. Research use only.
Is VIP FDA approved?
No. VIP is an investigational research-use-only compound - not for human or animal consumption and not FDA approved.
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External references: Peptide (Wikipedia) · U.S. Food and Drug Administration