Epithalon for Research

What is Epithalon?

Epithalon (Epitalon) is a synthetic tetrapeptide based on a naturally occurring pineal peptide. It is one of the most-cited peptides in longevity research because of its reported association with telomerase activity and telomere length in study models.

How Epithalon works (research mechanism)

Epithalon research focuses on potential activation of telomerase - the enzyme that maintains telomeres - and on pineal/melatonin-axis regulation, both of which are longevity-research variables.

Primary research applications

Telomere and longevity research

The central research theme, studying telomerase and cellular-aging endpoints.

Pineal / circadian research

Examined for melatonin-axis and sleep-regulation variables.

Cellular-aging models

Used in broad aging-research designs.

Research dosing reference

Research references commonly cite 1 mg daily across a 10-day cycle, repeated every 3-6 months. Reference values only.

Reconstitution & handling

Epithalon ships as a lyophilized (freeze-dried) powder and must be reconstituted before use in any liquid research model. Allow the vial to reach room temperature, swab the stopper, then add bacteriostatic water slowly down the inside wall of the vial - never spray it directly onto the powder. Swirl gently until dissolved; do not shake, as shaking foams the solution and stresses the peptide. The volume of water you add sets the concentration: a 5 mg vial reconstituted with 2 mL yields 2,500 mcg/mL, so 0.1 mL measures 250 mcg. A correctly reconstituted Epithalon solution is clear; discard if it is cloudy or shows particulate.

Storage & stability

Store un-reconstituted Epithalon vials refrigerated and protected from light for long-term stability; the lyophilized form is robust and tolerates shipping. After reconstitution, refrigerate at 2-8C, keep away from light, and use within the typical research window of roughly two to four weeks. The benzyl alcohol in bacteriostatic water helps inhibit microbial growth across that period. Always label reconstituted vials with the concentration and date.

Common research pairings

Studied as a standalone longevity peptide, sometimes alongside Thymosin Alpha-1 in aging-research designs.

How Epithalon compares

Epithalon is studied for telomere/longevity endpoints specifically, distinguishing it from immune-focused Thymosin Alpha-1 and cognitive peptides.

Safety & research considerations

Epithalon is a research chemical not approved for human use. For laboratory research only.

Sourcing, purity & Certificate of Analysis

Every lot of Epithalon sold by Peptides Factory Direct is third-party tested to a 99%+ purity target, with identity confirmed by mass spectrometry and purity quantified by HPLC. A Certificate of Analysis (COA) documenting these results is available on request and ties each vial to a tracked lot. Material ships nationwide to all 50 US states with cold-chain handling where appropriate and fast domestic dispatch. This documentation is what separates research-grade Epithalon from unverified material - quality is established before the vial ever reaches your lab.

How to order Epithalon for research

Epithalon can be ordered through the Peptides Factory Direct research portal as a one-time purchase or on a recurring research schedule (every 2 weeks, monthly, every 2 months, or every 3 months). Checkout requires confirming you are 21 or older, purchasing for laboratory research only, and that the product is not for human or animal consumption. Bulk and standing-order pricing is available - note it in your order. Open the order portal to view current research sizes and pricing.

Frequently asked questions

Related Anti-Aging & Longevity peptides

All Anti-Aging & Longevity peptides · Research guides & articles

External references: Peptides (Wikipedia) · U.S. Food and Drug Administration